Rosie O’Donnell Says She Has Lost Nearly 60 Lbs. With Mounjaro Since Moving to Ireland

Rosie O’Donnell has found a fresh start, and a healthier future, by leaving America.

The A League of Their Own star, who fled to Ireland when longtime rival Donald Trump returned to office in 2025, took to Instagram on Tuesday, April 28 to post an image of a Women.com article which noted that her “Mounjaro face transformation is undeniable.”

“I have diabetes 2. I have lost 56 lbs. in just over 3 years — I’m thankful for my improved health,” O’Donnell, 64, captioned the post.

While the prescription drug is designed to regulate blood sugar levels in people with type 2 diabetes, many users experience moderate weight loss as a side effect.

Since relocating to the Dublin area with her child Clay, 13, the former View cohost says her wellbeing has improved dramatically. She told another fan in her Instagram replies she was taking things “slow and steady”.

In a March TikTok video, she explained that leaving the U.S. helped her escape the stress and anxiety she felt amid political tensions and her decades-long feud with Trump, which dates back more than 20 years.

O’Donnell also said she was enjoying the milestones around her weight loss, including shopping for new clothes after dropping from a size 2XL to a large.

The star is mom to five kids, including Clay: Parker, 30, Chelsea, 28, Blake, 26, Vivienne, 23.